Baseline correction for the dose-response matrix of drug combinations

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Description

A function to do baseline correction on the dose-response matrix for drug combinations with a weighted correction fator

Usage

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BaselineCorrectionSD(response.mat, Emin = NA, Emax = NA,
  nan.handle = c("LL4", "L4"))

Arguments

response.mat

a dose-response matrix with concentrations as row names and column names.

Emin

the minimal effect of the drug used in the 4-parameter log-logistic function to fit the dose-response curve. If it is not NA, it is fixed the value assigned by the user. Defaults to NA.

Emax

the maximal effect of the drug used in the 4-parameter log-logistic function to fit the dose-response curve. If it is not NA, it is fixed the value assigned by the user. Defaults to NA.

nan.handle

a parameter to specify if L.4 function or LL.4 function is used when fitting with LL.4 produces NaNs.

Value

A list of the original dose-response matrix without correction and the corrected dose-response matrix.

Author(s)

Liye He liye.he@helsinki.fi, Jing Tang jing.tang@helsinki.fi

Examples

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data("mathews_screening_data")
data <- ReshapeData(mathews_screening_data)
data <- BaselineCorrectionSD(data$dose.response.mats[[1]])