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# ______ __
# / ____/_ __/ /_ ___
# / / / / / / __ \/ _ \
# / /___/ /_/ / /_/ / __/
# \____/\__,_/_.___/\___/
#
# MGDrivE: Mosquito Gene Drive Explorer
# RIDL
# Héctor Sanchez, Jared Bennett, Sean Wu, John Marshall
# August 2017
# Jared_Bennett@berkeley.edu
#
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#' Inheritance Cube: RIDL (Release of Insects with Dominant Lethality)
#'
#' This function creates a RIDL system.
#' RIDL (Release of Insects with Dominant Lethality), is a form of SIT.
#' Created by Oxitec, this is based on a positive feedback loop using the
#' toxic tTAV gene, controlled under lab conditions by the TetO promoter.
#' This has 2 alleles at 1 locus
#' * W: Wild-type allele
#' * R: OX513 RIDL allele
#'
#' @param eta Genotype-specific mating fitness
#' @param phi Genotype-specific sex ratio at emergence
#' @param omega Genotype-specific multiplicative modifier of adult mortality
#' @param xiF Genotype-specific female pupatory success
#' @param xiM Genotype-specific male pupatory success
#' @param s Genotype-specific fractional reduction(increase) in fertility
#'
#' @return Named list containing the inheritance cube, transition matrix, genotypes, wild-type allele,
#' and all genotype-specific parameters.
#' @export
cubeRIDL <- function(eta = NULL, phi = NULL, omega = NULL, xiF = NULL, xiM = NULL, s = NULL){
gtype <- c('WW', 'WR', 'RR')
size <- length(gtype) #because I use it several times
tMatrix <- array(data=0, dim=c(size, size, size), dimnames=list(gtype, gtype, gtype)) #transition matrix
## fill tMatrix with probabilities
#( 'rr', 'rR', 'RR')
tMatrix['WW','WW', ] <- c( 1, 0, 0)
tMatrix['WR','WW', ] <- c( 1/2, 1/2, 0)
tMatrix['WR','WR', ] <- c( 1/4, 1/2, 1/4)
tMatrix['RR','WW', ] <- c( 0, 1, 0)
tMatrix['RR','WR', ] <- c( 0, 1/2, 1/2)
tMatrix['RR','RR', ] <- c( 0, 0, 1)
## set the other half of the matrix
# Boolean matrix for subsetting, used several times
boolMat <- upper.tri(x = tMatrix[ , ,1], diag = FALSE)
# loop over depth, set upper triangle
for(z in 1:size){tMatrix[ , ,z][boolMat] <- t(tMatrix[ , ,z])[boolMat]}
## initialize viability mask. No mother-specific death, so use basic mask
viabilityMask <- array(data = 1, dim = c(size,size,size), dimnames = list(gtype, gtype, gtype))
## genotype-specific modifiers
modifiers = cubeModifiers(gtype, eta = eta, phi = phi, omega = omega, xiF = xiF, xiM = xiM, s = s)
## put everything into a labeled list to return
return(list(
ih = tMatrix,
tau = viabilityMask,
genotypesID = gtype,
genotypesN = size,
wildType = "WW",
eta = modifiers$eta,
phi = modifiers$phi,
omega = modifiers$omega,
xiF = modifiers$xiF,
xiM = modifiers$xiM,
s = modifiers$s,
releaseType = "RR"
))
}
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