R/TTest.R

In Mediana: Clinical Trial Simulations

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# Function: TTest .
# Argument: Data set and parameter (call type).
# Description: Computes one-sided p-value based on two-sample t-test.

TTest = function(sample.list, parameter) {

  # Determine the function call, either to generate the p-value or to return description
  call = (parameter[[1]] == "Description")

  if (call == FALSE | is.na(call)) {

    # No parameters are defined
    if (is.na(parameter[[2]])) {
      larger = TRUE
    }
    else {
      # Check the name of arguments
      if (!all(names(parameter[[2]]) %in% c("larger"))) stop("Analysis model: Ttest test: this function accepts only one argument (larger)")
      # larger argument
      if (!is.logical(parameter[[2]]$larger)) stop("Analysis model: TTest test: the larger argument must be logical (TRUE or FALSE).")
      larger = parameter[[2]]$larger
    }

    # Sample list is assumed to include two data frames that represent two analysis samples

    # Outcomes in Sample 1
    outcome1 = sample.list[[1]][, "outcome"]
    # Remove the missing values due to dropouts/incomplete observations
    outcome1.complete = outcome1[stats::complete.cases(outcome1)]

    # Outcomes in Sample 2
    outcome2 = sample.list[[2]][, "outcome"]
    # Remove the missing values due to dropouts/incomplete observations
    outcome2.complete = outcome2[stats::complete.cases(outcome2)]

    # One-sided p-value (treatment effect in sample 2 is expected to be greater than in sample 1)
    if (larger) result = stats::t.test(outcome2.complete, outcome1.complete, alternative = "greater")$p.value
    else result = stats::t.test(outcome2.complete, outcome1.complete, alternative = "less")$p.value

  }
  else if (call == TRUE) {
    result=list("Student's t-test")
  }

  return(result)
}
# End of TTest