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# Slope variance estimation based on block-bootstrap
SLOPE_var<-function(Y,tmsSec,Nboot=50,Num=10,alpha=0.3)
{
Gut = Y
if(sum(Gut==15,na.rm = T)>0)
{
Slope_imput = Slope_withinvar = vector()
for(i in 1:Num)
{
Gut_MI = Gut
Gut_MI[(Gut_MI==15)] = runif(sum((Gut_MI==15)),0,15)
Gut_hat = predict(lm(Gut_MI~tmsSec))
Slope_imput[i] = coef(lm(Gut_hat~tmsSec))[2]
Gut_res = Gut_MI - Gut_hat
B_tres = blkboot(Gut_res,R=50)
Slope_withinvar[i] = var(apply(B_tres,2,function(x){ y = x+Gut_hat; yhat = predict(loess(y~tmsSec, span=alpha )); slope = coef(lm(yhat~tmsSec))[2] }))
}
return( var(Slope_imput)*(1+1/Num) + mean(Slope_withinvar) )
}else
{
Gut_MI = Gut
Gut_hat = predict(lm(Gut_MI~tmsSec))
Gut_res = Gut_MI - Gut_hat
B_tres = blkboot(Gut_res,R=50)
return( var(apply(B_tres,2,function(x){ y = x+Gut_hat; yhat = predict(loess(y~tmsSec, span=alpha )); slope = coef(lm(yhat~tmsSec))[2] })) )
}
}
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