This data set consists of gene expression and DNA copy number measurements on a set of 89 samples. This example is used in Witten, Tibshirani and Hastie (2008).
The format is a list containing the following elements: - dna: a 2149x89 matrix of CGH spots x Samples - rna: a 19672x89 matrix of Genes x Samples - chrom: a 2149-vector of chromosomal location of each CGH spot - nuc: a 2149-vector of nucleotide position for each CGH spot - gene: a 19672-vector wiith an accession number for each gene - genenames: a 19672-vector with a name for each gene - genechr: a 19672-vector with a chromosomal location for each gene - genedesc: a 19672-vector with a description for each gene - genepos: a 19672-vector with a nucleotide position for each gene
This data set can be used to perform integrative analysis of gene expression and DNA copy number data, as in e.g. Witten and Tibshirani and Hastie (2008). That is, we can look for sets of genes that are associated with regions of chromosomal gain/loss.
Missing values were imputed using 5-nearest neighbors (see library pamr).
This data set was published in the following paper:
Chin, K., DeVries, S., Fridlyand, J., Spellman, P., Roydasgupta, R., Kuo,W.-L., Lapuk, A., Neve, R., Qian, Z., Ryder, T., Chen, F., Feiler, H., Tokuyasu, T., Kingsley, C., Dairkee, S., Meng, Z., Chew, K., Pinkel, D., Jain, A., Ljung, B., Esserman, L., Albertson, D.,Waldman, F. & Gray, J. (2006), 'Genomic and transcriptional aberrations linked to breast cancer pathophysiologies', Cancer Cell 10, 529-541.
It is publicly available at http://icbp.lbl.gov/breastcancer .
Chin, DeVries, Fridlyand, et al. (2006) Cancer Cell 10, 529-541.
Used as an example in Witten, Tibshirani and Hastie (2008) 'A penalized matrix decomposition, with applications to sparse principal components and canonical correlation analysis.'
1 2 3 4
Loading required package: plyr Loading required package: impute
Add the following code to your website.
For more information on customizing the embed code, read Embedding Snippets.