Nothing
ui.modules_pancan_anatomy <- function(id) {
ns <- NS(id)
fluidPage(
fluidRow(
column(
wellPanel(
shinyWidgets::prettyRadioButtons(
inputId = ns("profile"), label = "Select a genomic profile:",
choiceValues = c("mRNA", "transcript", "methylation", "protein", "miRNA", "cnv_gistic2", "cnv"),
choiceNames = c("mRNA Expression", "Transcript Expression", "DNA Methylation", "Protein Expression", "miRNA Expression", "Copy Number Variation", "Copy Number Variation (thresholded)"),
animation = "jelly"
),
selectizeInput(
inputId = ns("Pancan_search"),
label = "Input a gene or formula (as signature)",
choices = NULL,
width = "100%",
options = list(
create = TRUE,
maxOptions = 5,
placeholder = "Enter a gene symbol, e.g. TP53",
plugins = list("restore_on_backspace")
)
),
shinyBS::bsPopover(ns("Pancan_search"),
title = "Tips",
content = "Enter a gene symbol to show its pan-can distribution, e.g. TP53",
placement = "right", options = list(container = "body")
),
selectInput(inputId = ns("Gender"), label = "Select Gender for plot", choices = c("Male", "Female"), selected = "Female"),
tags$hr(style = "border:none; border-top:2px solid #5E81AC;"),
shinyWidgets::actionBttn(
inputId = ns("search_bttn"),
label = "Go!",
style = "gradient",
icon = icon("search"),
color = "primary",
block = TRUE,
size = "sm"
)
),
wellPanel(
numericInput(inputId = ns("height"), label = "Height", value = 5),
numericInput(inputId = ns("width"), label = "Width", value = 10),
prettyRadioButtons(
inputId = ns("device"),
label = "Choose plot format",
choices = c("pdf", "png"),
selected = "pdf",
inline = TRUE,
icon = icon("check"),
animation = "jelly",
fill = TRUE
),
downloadBttn(
outputId = ns("download"),
style = "gradient",
color = "default",
block = TRUE,
size = "sm"
),
),
tags$a(href = "https://toil.xenahubs.net/", "Genomic profile data source"),
width = 3
),
column(
plotOutput(ns("pancan_anatomy"), height = "500px",width = "650px"),
hr(),
h5("NOTEs:"),
p("1. GISTIC2 thresholded copy number -2,-1,0,1,2, representing homozygous deletion,single copy deletion,diploid normal copy,low-level copy number amplification,or high-level copy number amplification"),
tags$br(),
p("2. ",tags$a(href = "https://pancanatlas.xenahubs.net/", "Genomic profile data source")),
DT::DTOutput(outputId = ns("tbl")),
shinyjs::hidden(
wellPanel(
id = ns("save_csv"),
downloadButton(ns("downloadTable"), "Save as csv")
)
),
width = 9
)
)
)
}
server.modules_pancan_anatomy <- function(input, output, session) {
ns <- session$ns
profile_choices <- reactive({
switch(input$profile,
mRNA = list(all = pancan_identifiers$gene, default = "TP53"),
methylation = list(all = pancan_identifiers$gene, default = "TP53"),
protein = list(all = pancan_identifiers$protein, default = "P53"),
transcript = list(all = load_data("transcript_identifier"), default = "ENST00000000233"),
miRNA = list(all = pancan_identifiers$miRNA, default = "hsa-miR-769-3p"),
cnv_gistic2 = list(all = pancan_identifiers$gene, default = "TP53"),
cnv = list(all = pancan_identifiers$gene, default = "TP53"),
list(all = "NONE", default = "NONE")
)
})
observe({
updateSelectizeInput(
session,
"Pancan_search",
choices = profile_choices()$all,
selected = profile_choices()$default,
server = TRUE
)
})
# Show waiter for plot
w <- waiter::Waiter$new(id = ns("pancan_anatomy"), html = waiter::spin_hexdots(), color = "white")
plot_func <- eventReactive(input$search_bttn, {
if (nchar(input$Pancan_search) >= 1) {
out <- vis_pancan_anatomy(
Gene = input$Pancan_search,
Gender = input$Gender,
data_type = input$profile
)
return(out)
}
})
observeEvent(input$search_bttn, {
if (nchar(input$Pancan_search) >= 1) {
shinyjs::show(id = "save_csv")
} else {
shinyjs::hide(id = "save_csv")
}
})
output$tbl <- renderDT(
plot_func()$data,
options = list(lengthChange = FALSE)
)
output$downloadTable <- downloadHandler(
filename = function() {
paste0(input$Pancan_search, "_", input$profile, "_pancan_anatomy.csv")
},
content = function(file) {
write.csv(plot_func()$data, file, row.names = FALSE)
}
)
output$pancan_anatomy <- renderPlot({
w$show() # Waiter add-ins
plot_func()$plot
})
output$download <- downloadHandler(
filename = function() {
paste0(input$Pancan_search, "_", input$profile, "_pancan_anatomy.", input$device)
},
content = function(file) {
p <- plot_func()$plot
if (input$device == "pdf") {
pdf(file, width = input$width, height = input$height)
print(p)
dev.off()
} else {
png(file, width = input$width, height = input$height, res = 600, units = "in")
print(p)
dev.off()
}
}
)
}
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