Results from Ewings-Sarcoma Experiments

Description

These data frames contain the results of a series of cytotoxicity experiments on cell-lines from the pediatric cancer Ewings' sarcoma. Data frames describe results from several different experiments or sets of experiments:

es1data

Experiment combining three PARP inhibitors with standard-of-care DNA damaging agents in the ES1 cell line.

es1extdata

Follow up experiments combining BMN 673 and SN-38 with several additional mechanistic classes in the ES1 cell line.

es8data

Experiment combining three PARP inhibitors with standard-of-care DNA damaging agents in the ES8 cell line.

es8extdata

Follow up experiments combining BMN 673 and SN-38 with several additional mechanistic classes in the ES8 cell line.

ew8data

Experiment combining three PARP inhibitors with standard-of-care DNA damaging agents in the EW8 cell line.

Usage

1
data(ewings)

Format

Data frames containing the following columns:

plate

The number of the plate this measurement was taken from

well

The name of the well (e.g. "A01") this measurement was taken from

compound1

The compound drugged in decreasing concentration across this plate (DMSO if none)

compound2

The compound drugged in decreasing concentration down this plate (DMSO if none)

conc1

The concentration (in molar) of the first compound in this well

conc2

The concentration (in molar) of the second compound in this well

act

The base-10 logarithm of CellTiter-Glo intensity in this well normalized to intensity in negative control wells on the same plate

date

The date on which the experiment using this plate was run