Fleiss93: Aspirin after Myocardial Infarction

Description Usage Format Source Examples

Description

Meta-analysis on aspirin in preventing death after myocardial infarction.

Data example in Fleiss (1993) for meta-analysis with binary outcomes.

Usage

1

Format

A data frame with the following columns:

study

Study label

year

Year of publication

event.e

Number of deaths in aspirin group

n.e

Number of observations in aspirin group

event.c

Number of deaths in placebo group

n.c

Number of observations in placebo group

Source

Fleiss JL (1993), The statistical basis of meta-analysis. Statistical Methods in Medical Research, 2, 121–145.

Examples

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data(Fleiss93)
metabin(event.e, n.e, event.c, n.c,
        data=Fleiss93,
        studlab=paste(study, year),
        sm="OR", comb.random=FALSE)

Example output

Loading 'meta' package (version 4.8-4).
Type 'help(meta)' for a brief overview.
                OR           95%-CI %W(fixed)
MRC-1 1974  0.7197 [0.4890; 1.0593]       3.2
CDP 1976    0.6808 [0.4574; 1.0132]       3.1
MRC-2 1979  0.8029 [0.6065; 1.0629]       5.7
GASP 1979   0.8007 [0.4863; 1.3186]       1.8
PARIS 1980  0.7981 [0.5526; 1.1529]       3.2
AMIS 1980   1.1327 [0.9347; 1.3728]      10.2
ISIS-2 1988 0.8950 [0.8294; 0.9657]      72.9

Number of studies combined: k = 7

                       OR           95%-CI     z  p-value
Fixed effect model 0.8969 [0.8405; 0.9570] -3.29   0.0010

Quantifying heterogeneity:
 tau^2 = 0.0096; H = 1.29 [1.00; 1.99]; I^2 = 39.7% [0.0%; 74.6%]

Test of heterogeneity:
    Q d.f.  p-value
 9.95    6   0.1269

Details on meta-analytical method:
- Mantel-Haenszel method

meta documentation built on June 8, 2018, 1:06 a.m.