Description Usage Arguments Author(s) References

Computes the MLE for a Hybrid Design in the pure ecological setting, with two binary covariates, Z and W, in the model. hybdesEco is specific to the model logit(P(Y=1)) = b0 + b1*Z + b2*W

1 |

`MM.Z` |
MM.Z is a matrix of margin totals for covariate Z. Rows are groups, columns are margin totals |

`MM.W` |
MM.W is a matrix of margin totals for covariate W. Rows are groups, columns are margin totals |

`NN` |
NN is a matrix of outcome margin totals. Rows are groups, columns are margin totals. NN is always a K x 2 matrix, where K is the number of groups |

`cc` |
cc is a list of case-control data. Each element is a table with joint Z-W exposure (rows) and outcome (columns) |

`aprx` |
Type of approximation to use when calculating the hybrid likelihood. Default is the binomial approximation. |

`start.mle` |
Starting value for the Newton-Raphson algorithm used to determine Hybrid Design MLE. |

`group.int` |
A logical indicator of whether or not groups should be treated as having different intercept parameters. |

E. Smoot

Smoot, E., and S. Haneuse. "On the Analysis of Hybrid Designs that Combine Group- and Individual-Level Data." Biometrics (in press, 2014).

osDesign documentation built on May 29, 2017, 8:45 p.m.

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