synergyfinder: Calculate and Visualize Synergy Scores for Drug Combinations

Efficient implementations for all the popular synergy scoring models for drug combinations, including HSA, Loewe, Bliss and ZIP and visualization of the synergy scores as either a two-dimensional or a three-dimensional interaction surface over the dose matrix.

Author
Liye He <liye.he@helsinki.fi>, Jing Tang <jing.tang@helsinki.fi>
Date of publication
2016-05-04 10:02:51
Maintainer
Liye He <liye.he@helsinki.fi>
License
Artistic License 2.0
Version
0.1

View on CRAN

Man pages

BaselineCorrectionSD
Baseline correction for the dose-response matrix of drug...
BaselineCorrectionSD
Baseline correction for the dose-response matrix of drug...
Bliss
Synergy score based on Bliss model
Bliss
Synergy score based on Bliss model
CalculateSynergy
Calculate the synergy scores for drug combinations
CalculateSynergy
Calculate the synergy scores for drug combinations
FittingSingleDrug
Fitting single drug dose-response curve
FittingSingleDrug
Fitting single drug dose-response curve
HSA
HSA synergy score based on highest single agent (HSA) model
HSA
HSA synergy score based on highest single agent (HSA) model
Loewe
Delta synergy score based on Loewe model
Loewe
Delta synergy score based on Loewe model
mathews_screening_data
A high-throughput drug combination screening data
mathews_screening_data
A high-throughput drug combination screening data
PlotDoseResponse
Visualize the drug combination dose-response data
PlotDoseResponse
Visualize the drug combination dose-response data
PlotSynergy
Drug interaction landscape
PlotSynergy
Drug interaction landscape
ReshapeData
Transform the response data from the data frame format to...
ReshapeData
Transform the response data from the data frame format to...
ZIP
Delta synergy score based on zero interaction potency (ZIP)...
ZIP
Delta synergy score based on zero interaction potency (ZIP)...

Files in this package

synergyfinder/DESCRIPTION
synergyfinder/NAMESPACE
synergyfinder/R
synergyfinder/R/Bliss.R
synergyfinder/R/Calculate_score.R
synergyfinder/R/Correct_plate.R
synergyfinder/R/Fitting_single_drug.R
synergyfinder/R/HSA.R
synergyfinder/R/Loewe.R
synergyfinder/R/Plot_dose_response.R
synergyfinder/R/Plot_synergy.R
synergyfinder/R/Reshape_data.R
synergyfinder/R/ZIP.R
synergyfinder/R/mathews_screening_data.R
synergyfinder/data
synergyfinder/data/mathews_screening_data.rda
synergyfinder/man
synergyfinder/man/BaselineCorrectionSD.Rd
synergyfinder/man/Bliss.Rd
synergyfinder/man/CalculateSynergy.Rd
synergyfinder/man/FittingSingleDrug.Rd
synergyfinder/man/HSA.Rd
synergyfinder/man/Loewe.Rd
synergyfinder/man/PlotDoseResponse.Rd
synergyfinder/man/PlotSynergy.Rd
synergyfinder/man/ReshapeData.Rd
synergyfinder/man/ZIP.Rd
synergyfinder/man/mathews_screening_data.Rd