Bioconductor-mirror/RTN: Reconstruction of transcriptional networks and analysis of master regulators

This package provides classes and methods for transcriptional network inference and analysis. Modulators of transcription factor activity are assessed by conditional mutual information, and master regulators are mapped to phenotypes using different strategies, e.g., gene set enrichment, shadow and synergy analyses. Additionally, master regulators can be linked to genetic markers using eQTL/VSE analysis, taking advantage of the haplotype block structure mapped to the human genome in order to explore risk-associated SNPs identified in GWAS studies.

Getting started

Package details

AuthorMauro Castro, Xin Wang, Michael Fletcher, Florian Markowetz and Kerstin Meyer
Bioconductor views GeneExpression GeneRegulation GeneSetEnrichment GeneticVariability GraphAndNetwork NetworkEnrichment NetworkInference SNP
MaintainerMauro Castro <[email protected]>
Package repositoryView on GitHub
Installation Install the latest version of this package by entering the following in R:
Bioconductor-mirror/RTN documentation built on July 16, 2017, 5:15 a.m.