Bioconductor-mirror/birta: Bayesian Inference of Regulation of Transcriptional Activity
Version 1.21.0

Expression levels of mRNA molecules are regulated by different processes, comprising inhibition or activation by transcription factors and post-transcriptional degradation by microRNAs. birta (Bayesian Inference of Regulation of Transcriptional Activity) uses the regulatory networks of TFs and miRNAs together with mRNA and miRNA expression data to predict switches in regulatory activity between two conditions. A Bayesian network is used to model the regulatory structure and Markov-Chain-Monte-Carlo is applied to sample the activity states.

Getting started

Package details

AuthorBenedikt Zacher, Khalid Abnaof, Stephan Gade, Erfan Younesi, Achim Tresch, Holger Froehlich
Bioconductor views GeneExpression GraphAndNetwork Microarray Sequencing Transcription
MaintainerBenedikt Zacher <zacher@lmb.uni-muenchen.de>, Holger Froehlich <frohlich@bit.uni-bonn.de>
LicenseGPL (>= 2)
Version1.21.0
Package repositoryView on GitHub
Installation Install the latest version of this package by entering the following in R:
install.packages("devtools")
library(devtools)
install_github("Bioconductor-mirror/birta")
Bioconductor-mirror/birta documentation built on June 1, 2017, 5:22 a.m.