NONMEM is a FORTRAN application for fitting mixed effects models. NONMEM licenses are available from ICON Development Solutions. Models are specified as plain text files called control files. The control file contains blocks corresponding to components of the model. Model results are presented as plain text files. These input and output files can be imported into R by RNMImport to facilitate model modification, model diagnostics, model interpretation and reporting.
# install devtools for devtools::install_github install.packages("devtools") library(devtools) # install RNMImport install_github("MangoTheCat/RNMImport") library(RNMImport)
A NONMEM execution including both input files and results files can
be read using
The imported object is S4 class 'NMRun'.
Various methods are available for extracting the model information.
theo1 <- importNm(conFile = "theoph.con", path = system.file(package = "RNMImport", "examples", "theoph")) slotNames(theo1)
The dataset can be extracted using
This contains the input data, and the model residuals and other
records requested when defining the model.
Model parameters can be extracted using methods corresponding to the parameter type.
getThetas(theo1) getOmegas(theo1) getSigmas(theo1)
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