README.md

In Sage-Bionetworks/fendR: Feature Engineering by Network Domain

fendr: From Expression (to) Novel Drug Response

This package represents our attempts to identify novel drugs and/or targets from transcriptomic and/or genomic data.

Installation

To get this to run we have not built a package yet but you can clone the repository as follows:

git clone https://github.com/Sage-Bionetworks/fendR/

Once you open the Rstudio project you can install the required packages:

install.packages('devtools')
devtools::install_github('sgosline/PCSF')
source("https://bioconductor.org/biocLite.R")
biocLite("viper")

Ongoing work

We are currently experimenting with:

1- Incorporating @allaway's drug-target network to quantify putative drug targets of novel drugs 2- Mapping gene expression data to proteins in the protein and or drug-target interaction networks

See development Directory for latest plans and updates

Sage-Bionetworks/fendR documentation built on May 3, 2019, 8:34 p.m.