Man pages for USEPA/CompTox-ExpoCast-httk
High-Throughput Toxicokinetics

add_chemtableAdd a table of chemical information for use in making httk...
age_dist_smoothSmoothed age distributions by race and gender.
age_draw_smoothDraws ages from a smoothed distribution for a given...
armitage_estimate_sareaEstimate well surface area
armitage_evalEvaluate the updated Armitage model
armitage_inputArmitage et al. (2014) Model Inputs from Honda et al. (2019)
available_rblood2plasmaFind the best available ratio of the blood to plasma...
blood_mass_correctFind average blood masses by age.
blood_weightPredict blood mass.
bmiageCDC BMI-for-age charts
body_surface_areaPredict body surface area.
bone_mass_agePredict bone mass.
brain_massPredict brain mass.
calc_analytic_cssCalculate the analytic steady state concentration.
calc_analytic_css_1compCalculate the analytic steady state concentration for the one...
calc_analytic_css_3compCalculate the analytic steady state concentration for model...
calc_analytic_css_3compssCalculate the analytic steady state concentration for the...
calc_analytic_css_pbtkCalculate the analytic steady state concentration for model...
calc_cssFind the steady state concentration and the day it is...
calc_elimination_rateCalculate the elimination rate for a one compartment model.
calc_hepatic_clearanceCalculate the hepatic clearance.
calc_ionizationCalculate the ionization.
calc_mc_cssFind the monte carlo steady state concentration.
calc_mc_oral_equivCalculate Monte Carlo Oral Equivalent Dose
calc_rblood2plasmaCalculate the constant ratio of the blood concentration to...
calc_statsCalculate the statistics.
calc_total_clearanceCalculate the total clearance.
calc_vdistCalculate the volume of distribution for a one compartment...
chem.invivo.PK.aggregate.dataParameter Estimates from Wambaugh et al. (2018)
chem.invivo.PK.dataPublished toxicokinetic time course measurements
chem.invivo.PK.summary.dataSummary of published toxicokinetic time course experiments
chem.listsChemical membership in different research projects
chem.physical_and_invitro.dataPhysico-chemical properties and in vitro measurements for...
ckd_epi_eqCKD-EPI equation for GFR.
convert_httkConverts HTTK-Pop virtual population into parameters relevant...
draw_fup_clintDraw Funbound.plasma and Clint from censored or non-censored...
estimate_gfrPredict GFR.
estimate_gfr_pedPredict GFR in children.
estimate_hematocritPredict hematocrit using smoothing spline.
export_pbtk_jarnacExport model to jarnac.
export_pbtk_sbmlExport model to sbml.
gen_age_height_weightGenerate ages, heights, and weights for a virtual population...
gen_height_weightGenerate heights and weights for a virtual population.
get_chem_idRetrieve chemical identity from HTTK package
get_cheminfoRetrieve chemical information from HTTK package
get_gfr_categoryCategorize kidney function by GFR.
get_httk_paramsConverts the HTTK-Pop population data table to a table of the...
get_lit_cheminfoGet literature Chemical Information.
get_lit_cssGet literature Css
get_lit_oral_equivGet Literature Oral Equivalent Dose
get_physchem_paramGet physico-chemical parameters from...
get_rblood2plasmaGet ratio of the blood concentration to the plasma...
get_weight_classGiven vectors of age, BMI, recumbent length, weight, and...
hematocrit_infantsPredict hematocrit in infants under 1 year old.
honda.iviveReturn the assumptions used in Honda et al. 2019
howgateHowgate 2006
httk-package\Sexpr{tools:::Rd_package_title("httk")}
httkpophttkpop: Virtual population generator for HTTK.
httkpop_bioConvert HTTK-Pop-generated parameters to HTTK physiological...
httkpop_direct_resampleGenerate a virtual population by directly resampling the...
httkpop_direct_resample_innerInner loop function called by 'httkpop_direct_resample'.
httkpop_generateGenerate a virtual population
httkpop_virtual_indivGenerate a virtual population by the virtual individuals...
in.listConvenience Boolean (yes/no) functions to identify chemical...
is.httkConvenience Boolean (yes/no) function to identify chemical...
is_in_inclusiveChecks whether a value, or all values in a vector, is within...
johnsonJohnson 2006
kidney_mass_childrenPredict kidney mass for children.
liver_mass_childrenPredict liver mass for children.
load_sipes2017Load data from Sipes et al 2017.
lump_tissuesLump tissue parameters
lung_mass_childrenPredict lung mass for children.
mcnally_dtReference tissue masses and flows from tables in McNally et...
monte_carloMonte Carlo for pharmacokinetic models
nhanes_mec_svyPre-processed NHANES data.
Obach2008Published Pharmacokinetic Parameters from Obach et al. 2008
onlypNHANES Exposure Data
pancreas_mass_childrenPredict pancreas mass for children.
parameterize_1compParameterize_1comp
parameterize_3compParameterize_3comp
parameterize_pbtkParameterize_PBTK
parameterize_schmittParameterize Schmitt's method.
parameterize_steadystateParameterize_SteadyState
pc.dataPartition Coefficient Data
pharmaDRUGS|NORMAN: Pharmaceutical List with EU, Swiss, US...
physiology.dataSpecies-specific physiology parameters
predict_partitioning_schmittPredict partition coefficients using the method from Schmitt...
rfunRandomly draws from a one-dimensional KDE
r_left_censored_normReturns draws from a normal distribution with a lower...
sipes2017Sipes et al. 2017 data
sipes2017.tablePhysico-chemical properties and toxicokinetics, measured...
skeletal_muscle_massPredict skeletal muscle mass.
skeletal_muscle_mass_childrenPredict skeletal muscle mass for children.
skin_mass_bosgraPredict skin mass.
solve_1compSolve one compartment TK model
solve_3compSolve_3comp
solve_pbtkSolve_PBTK
spleen_mass_childrenPredict spleen mass for children.
spline_heightweightSmoothing splines for log height vs. age and log body weight...
spline_hematocritSmoothing splines for log hematocrit vs. age in months, and...
spline_serumcreatSmoothing splines for log serum creatinine vs. age in months,...
Tables.Rdata.stampA timestamp of table creation
tissue.dataTissue composition and species-specific physiology parameters
tissue_masses_flowsGiven a data.table describing a virtual population by the...
tissue_scaleAllometric scaling.
ToxCast2015subsetToxCast and Tox21 2015 Active Hit Calls (EPA)
wambaugh2019in vitro Toxicokinetic Data from Wambaugh et al. (submitted)
wambaugh2019.nhanesNHANES Chemical Intake Rates for chemicals in Wambaugh et al....
wambaugh2019.rawRaw Bayesian in vitro Toxicokinetic Data Analysis from...
wambaugh2019.seem3ExpoCast SEEM3 Consensus Exposure Model Predictions for...
well_paramMicrotiter Plate Well Descriptions for Armitage et al. (2014)...
Wetmore2012Published toxicokinetic predictions based on in vitro data...
Wetmore.dataPublished toxicokinetic predictions based on in vitro data
wflWHO weight-for-length charts
USEPA/CompTox-ExpoCast-httk documentation built on Sept. 10, 2019, 9:23 p.m.