README.md

MVMR

Installation

To install MVMR directly from the GitHub repository, first make sure you have the devtools package installed:

install.packages("devtools")

Then the MVMR package can be installed using:

library(devtools)
install_github("WSpiller/MVMR")

To update the package just run the install_github("WSpiller/MVMR") command again.

Description

We have written the MVMR R package to perform multivariable Mendelian randomization analyses, including heterogeneity statistics for assessing instrument strength and validity. The package accommodates any number of exposures greater than 1, and is currently comprised of two functions:

  1. The format_mvmr function is used to convert a data frame containing summary data into a set format for MVMR analyses.

  2. The mvmr function fits an IVW multivariable Mendelian randomization model using first order weights. The function returns an object of class MVMRIVW, containing regression estimates, estimated heterogeneity as a measure of instrument strength (Q_strength), and estimated heterogeneity as a measure of instrument validity (Q_valid). Estimation follows the method outlined in Sanderson et al, 2018.

Multivariable Mendelian randomization is implemented in a number of R packages such as TwoSampleMR, and MendelianRandomization, however, this package includes further sensitivity analyses leveraging information on causal effect heterogeneity across instruments. To incorporate these features and future developments we will continue to develop our own MVMR package to implement multivariable Mendelian randomization.

Citation

The corresponding paper has been published by the International Journal of Epidemiology, and can be accessed at:

An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings. International Journal of Epidemiology, 2018. [Internet]. 2018;dyy262.

License

This project is licensed under GNU GPL v3.



WSpiller/MVMR documentation built on May 18, 2019, 1:30 p.m.