inst/shiny-examples/parameters.md

In asancpt/busulfansim: Simulation of Plasma Busulfan Concentrations by Using Population Pharmacokinetic Model

Parameters

• CMAX: maximum concentration, Cmax
• CMAXD: CMAX / Dose, Cmax / Dose
• TMAX: time of maximum concentration, Tmax
• TLAG: time until first nonzero concentration, for extravascular administration only
• CLST: last positive concentration observed, Clast
• CLSTP: last positive concentration predicted, Clast_pred
• TLST: time of last positive concentration, Tlast
• LAMZHL: half-life by lambda z, ln(2)/LAMZ
• LAMZ: lambda_z negative of best fit terminal slope
• LAMZLL: earlist time for LAMZ
• LAMZUL: last time for LAMZ
• LAMZNPT: number of points for LAMZ
• CORRXY: correlaton of log(concentration) and time
• R2: R-squared
• R2ADJ: R-squared adjusted
• C0: back extrapolated concentration at time 0, for bolus intravascular administration only
• AUCLST: AUC from 0 to TLST
• AUCALL: AUC using all the given points, including trailing zero concentrations
• AUCIFO: AUC infinity observed
• AUCIFOD: AUCIFO / Dose
• AUCIFP: AUC infinity predicted using CLSTP instead of CLST
• AUCIFPD: AUCIFP / Dose
• AUCPEO: AUC % extrapolation observed
• AUCPEP: AUC % extrapolated for AUCIFP
• AUCPBEO: AUC % back extrapolation observed, for bolus IV administration only
• AUCPBEP: AUC % back extrapolation predicted with AUCIFP, for bolus IV administration only
• AUMCLST: AUMC to the TLST
• AUMCIFO: AUMC infinity observed using CLST
• AUMCIFP: AUMC infinity determiend by CLSTP
• AUMCPEO: AUMC % extrapolated observed
• AUMCPEP: AUMC % extrapolated predicted
• MRTIVLST: mean residence time(MRT) to TLST, for intravascular administration
• MRTIVIFO: mean residence time(MRT) infinity using CLST, for intravascular administration
• MRTIVIFP: mean residence time(MRT) infinity ucinsg CLSTP, for intravascular administration
• MRTEVLST: mean residence time(MRT) to TLST, for extravascular administration
• MRTEVIFO: mean residence time(MRT) infinity using CLST, for extravascular administration
• MRTEVIFP: mean residence time(MRT) infinity ucinsg CLSTP, for extravascular administration
• VZO: volume of distribution determined by LAMZ and AUCIFO, for intravascular administration
• VZP: volume of distribution determined by LAMZ and AUCIFP, for intravascular administration
• VZFO: VZO for extravascular administration, VZO/F, F is bioavailability
• VZFP: VZP for extravascular administration, VZP/F, F is bioavailability
• CLO: clearance using AUCIFO, for intravascular administration
• CLP: clearance using AUCIFP, for intravascular administration
• CLFO: CLO for extravascular administration, CLO/F, F is bioavailability
• CLFP: CLP for extravascular administration, CLP/F, F is bioavailability
• VSSO: volume of distribution at steady state using CLST, for intravascular administration only
• VSSP: volume of distribution at stead state using CLSTP, for intravascular administration only

asancpt/busulfansim documentation built on May 31, 2019, 8:40 a.m.