bozdaglab/CTDPathSim: CTDPathSim: Cell line-tumor deconvoluted pathway-based similarity in the context of precision medicine in cancer

CTDPathSim is a computational pipeline to compute similarity scores between patient samples and cell lines using a pathway activity-based approach. CTDPathSim integrates sample-specific expression and methylation profiles utilizing a deconvolution method. CTDPathSim has four main computational steps. Step 1. Computing sample-specific deconvoluted methylation profile. Step 2. Computing sample-specific deconvoluted expression profile. Step 3. Computing sample and cell line-specific biological pathways. Step 4. Computing sample-cell line pathway activity-based similarity score.

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Package details

Bioconductor views DifferentialExpression DifferentialMethylation GO GeneExpression GeneRegulation Network Pathways Reactome
Licensefile LICENSE
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bozdaglab/CTDPathSim documentation built on Dec. 21, 2020, 1:14 p.m.