CTDPathSim is a computational pipeline to compute similarity scores between patient samples and cell lines using a pathway activity-based approach. CTDPathSim integrates sample-specific expression and methylation profiles utilizing a deconvolution method. CTDPathSim has four main computational steps. Step 1. Computing sample-specific deconvoluted methylation profile. Step 2. Computing sample-specific deconvoluted expression profile. Step 3. Computing sample and cell line-specific biological pathways. Step 4. Computing sample-cell line pathway activity-based similarity score.
|Bioconductor views||DifferentialExpression DifferentialMethylation GO GeneExpression GeneRegulation Network Pathways Reactome|
|Package repository||View on GitHub|
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