The keyboard design is a Bayesian model-based design that relies on the posterior distribution of the toxicity probability to guide dose escalation and de-escalation in order to find the maximum tolerated dose (MTD) in phase I clinical trials. The innovation is that the keyboard design defines a series of equal-width dosing intervals (or keys) to present the potential locations of the true toxicity of a dose and guide the dose escalation and de-escalation based on whether the strongest key, defined as the dosing interval that most likely contains the current dose, is below or above the target dosing interval. It can be used to design both single-agent and drug-combination trials. Software freely available at http://trialdesign.org/one-page-shell.html#Keyboard facilitates the application of the keyboard design.
|Author||Hongying Sun, Jose Pastrana and Haitao Pan|
|Maintainer||Haitao Pan <[email protected]>|
|Package repository||View on GitHub|
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