hongyingsun1101/KEYBOARD: A Bayesian Interval Design for Phase I/II Clinical Trials

The keyboard design is a Bayesian model-based design that relies on the posterior distribution of the toxicity probability to guide dose escalation and de-escalation in order to find the maximum tolerated dose (MTD) in phase I clinical trials. The innovation is that the keyboard design defines a series of equal-width dosing intervals (or keys) to present the potential locations of the true toxicity of a dose and guide the dose escalation and de-escalation based on whether the strongest key, defined as the dosing interval that most likely contains the current dose, is below or above the target dosing interval. It can be used to design both single-agent and drug-combination trials. Software freely available at http://trialdesign.org/one-page-shell.html#Keyboard facilitates the application of the keyboard design.

Getting started

Package details

AuthorHongying Sun, Jose Pastrana and Haitao Pan
MaintainerHaitao Pan <[email protected]>
Package repositoryView on GitHub
Installation Install the latest version of this package by entering the following in R:
hongyingsun1101/KEYBOARD documentation built on Jan. 1, 2020, 1:03 p.m.