Meta-Analysis of Region-Based Tests of Rare DNA Variants
Computes necessary information to meta analyze region-based tests for rare genetic variants (e.g. SKAT, T1) in individual studies, and performs meta analysis.
the latest released version from CRAN with
r
install.packages("seqMeta")
the latest development version from github with
r
if (packageVersion("devtools") < 1.6) {
install.packages("devtools")
}
devtools::install_github("DavisBrian/seqMeta")
If you encounter a clear bug, please file a minimal reproducible example on github.
any(is.na(Z))
with anyNA(Z)
prepScores2 is a drop in replacement for prepScores, prepScoresX and prepCox. The only difference is the family argument should be text. gaussian()
becomes "gaussian"
, binomial()
becomes "binomial"
and "cox"
is used for survival models. prepScores2 is much faster in cases where genotype imputation occurs.
apply
code with a faster vectorized version.any(is.na(Z))
with anyNA(Z)
range
with min
and max
t(x)%*%y
with crossprod(x, y)
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