seqDesign
is a versatile R package implementing a spectrum of event-driven and fixed follow-up preventive vaccine efficacy trial designs including designs of Gilbert P. B., Grove D. et al. (2011), A Sequential Phase 2b Trial Design for Evaluating Vaccine Efficacy and Immune Correlates for Multiple HIV Vaccine Regimens, Statistical Communications in Infectious Diseases, 3(1):1037.
Check out the following two vignettes, in this order, for a brief introduction to the package: Instructions for Using seqDesign and Generating the Output PDF Report, and seqDesign's Report Template.
The latter includes a report template PDF as well as the underlying code (Latex + R included in an Rnw file).
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