In mskilab/fragCounter: GC mappability correction and segmentation

knitr::opts_chunk$set(
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fragCounter

The goal of fragCounter is to correct Whole genome or targeted sequencing data for GC and mappability bias. The GC bias curve is determined by loess regression of read count by GC and mappability scores. Segmentation is done by circular binary segmentation (CBS) algorithm after getting tumor/normal ratios of corrected read counts.

Installation

You can install fragCounter from github with:

Install dependent packages

install.packages('DNAcopy')

Install devtools from CRAN (if you don't have it already)

install.packages('devtools')

Install dependent mskilab R packages

devtools::install_github('mskilab/gUtils')

Install fragCounter

devtools::install_github("mskilab/fragCounter")

Example

This is a basic example which shows you how to solve a common problem:

## basic example code

mskilab/fragCounter documentation built on Jan. 27, 2024, 2:35 p.m.