R/episet_full.R

In mytalbot/cms: Composite Measure Schemes for Severity Assessment in Animal Research

#' Full data set rat epilepsy experiment
#'
#' The data set entitled as „episet_full” contains data from five different studies. In these studies three different epilepsy models were 
#' investigated: a kindling model, an electrical and a chemical post-SE model. In all studies up to three different groups of animals were 
#' used. One group with implanted depth electrodes and generalized seizures (induced or spontaneous).
#' The animals of the second group were implanted with depth electrodes and the third group was completely naïve without implantation 
#' and seizures. The purpose of these studies was the identification and validation of parameters suitable for an objective 
#' severity assessment in rat epilepsy models. 
#' Therefore, several behavioral and biochemical parameters were investigated at different time points. To compare these three different 
#' models the most interesting period was the chronic phase with generalized seizures. Also, in this phase of the studies most parameters 
#' were assessed. For a more detailed description of the models and the studies please see the original published data [1-5]. 
#' 
#' 1.	Di Liberto, V., R. M. van Dijk, M. Brendel, A. M. Waldron, C. Möller, I. Koska, I. Seiffert, F. Gualtieri, F. J. Gildehaus,
#' B. von Ungern-Sternberg, M. Lindner, S. Ziegler, R. Palme, R. Hellweg, P. Gass, P. Bartenstein, and H. Potschka. 2018.
#' Imaging correlates of behavioral impairments: An experimental PET study in the rat pilocarpine epilepsy model. Neurobiology of 
#' disease 118: 9-21.  
#' 
#' 2.	Koska, I., R. M. van Dijk, I. Seiffert, V. Di Liberto, C. Möller, R. Palme, R. Hellweg, and H. Potschka. 2019.
#' Toward evidence-based severity assessment in rat models with repeated seizures: II. Chemical post-status epilepticus model. 
#' Epilepsia 60: 2114-2127.  
#' 
#' 3.	Möller, C., F. Wolf, R. M. van Dijk, V. Di Liberto, V. Russmann, M. Keck, R. Palme, R. Hellweg, P. Gass, C. Otzdorff, 
#' and H. Potschka. 2018. Toward evidence-based severity assessment in rat models with repeated seizures: I. Electrical kindling.
#' Epilepsia 59: 765-777.  
#' 
#' 4.	Seiffert, I., R. M. van Dijk, I. Koska, V. Di Liberto, C. Möller, R. Palme, R. Hellweg, and H. Potschka. 2019. 
#' Toward evidence-based severity assessment in rat models with repeated seizures: III. Electrical post-status epilepticus model. 
#' Epilepsia 60: 1539-1551.  
#' 
#' 5.	van Dijk, R. M., V. Di Liberto, M. Brendel, A. M. Waldron, C. Möller, F. J. Gildehaus, B. von Ungern-Sternberg, M. Lindner, 
#' S. Ziegler, R. Hellweg, P. Gass, P. Bartenstein, and H. Potschka. 2018. Imaging biomarkers of behavioral impairments: 
#' A pilot micro-positron emission tomographic study in a rat electrical post-status epilepticus model. Epilepsia 59: 2194-2205.  

#'
#' @docType data
#'
#' @usage data(episet_full)
#'
#' @format A 943 x 72 data frame with rat epilepsy data.
#'
#' @keywords datasets
#'
#' @examples
#' data(episet_full)
#' head(episet_full)
"episet_full"