R/data.R

In nanhung/rfast99: Global Sensitivity Analysis in Physiologically Based Kinetic Modeling

#' Pharmacokinetic Dataset of Acetaminophen
#'
#' The Acetaminophen dataset contains a human experiment of pharmacokinetic data
#' for acetaminophen and it's major metabolites acetaminophen-glucuronide and acetaminophen-sulfate.
#'
#' @references
#' Zurlinden, T. J., & Reisfeld, B. (2016).
#' Physiologically based modeling of the pharmacokinetics of acetaminophen and
#' its major metabolites in humans using a Bayesian population approach.
#' \emph{European journal of drug metabolism and pharmacokinetics}, 41(3), 267-280.
#'
#' @format A data frame containing the following columns:
#' \itemize{
#'   \item Wt: averaged weight of the study population (kg).
#'   \item Dose: given oral dose of acetaminophen administered (mg/kg).
#'   \item Time: time after drug administration (hr).
#'   \item APAP: concentration of acetaminophen in the sample (mg/L).
#'   \item AG: concentration of acetaminophen-glucuronide in the sample (mg/L).
#'   \item AS: concentration of acetaminophen-sulfate in the sample (mg/L).
#'   \item Study: sourced reference.
#' }
"APAP"