Contains functions necessary for evaluating, analyzing, and fitting combined action dose response surfaces with the Bivariate Response to Additive Interacting Dose (BRAID) model of combined action.
Package: | braidrm |
Type: | Package |
Version: | 0.71 |
Date: | 2016-03-07 |
License: | GPL (>= 3) |
A mathematical description of the BRAID surface model can be found in evalBRAIDrsm
. The heart of the package is the
function braidrm
, which takes a set of paired concentrations and measured responses and fits a particular
instantiation of the BRAID model to the data. Bootstrapped confidence intervals on all fit parameters can be constructed by
braidrm
, or afterwards by the function getBRAIDbootstrap
. Known BRAID surfaces can be evaluated or
inverted using the calculating functions evalBRAIDrsm
and invertBRAIDrsm
. As analysis of combined dose
response is closely linked to single agent dose response, we have provided several simple functions for analyzing such
relationships, such as findBestHill
. Finally, we also provide the more complete analytic functions
findBestBRAID
and runBRAIDanalysis
, which perform a series of BRAID surface fits (and in the case of
runBRAIDanalysis
, single agent fits) to simplify the process of implementing a BRAID analysis pipeline.
Nathaniel R. Twarog <nathaniel.twarog@stjude.org>
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