#' @title Generate a four-parent pedigree
#'
#' @description
#' Generate a four-parent pedigree starting from inbred founders, using a single funnel
#'
#' @details
#' Note that unlike \code{\link{fourParentPedigreeRandomFunnels}}, there is no intercrossing allowed in the single funnel case because the relevant haplotype probabilities assume randomly chosen funnels
#' @seealso \code{\link{fourParentPedigreeRandomFunnels}}, \code{\link{twoParentPedigree}}
#' @param initialPopulationSize The number of F1 lines generated
#' @param selfingGenerations The number of selfing generations at the end of the pedigree
#' @param nSeeds The number of progeny taken from each intercrossing line, or from each F1 if no intercrossing is specified. These lines are then selfed according to selfingGenerations
#' @param intercrossingGenerations The number of generations of intercrossing, after each F2 line is generated.
#' @return An object of class \code{detailedPedigree} representing the experimental design, suitable for simulation using simulateMPCross.
#' @export
fourParentPedigreeSingleFunnel <- function(initialPopulationSize, selfingGenerations, nSeeds = 1L, intercrossingGenerations)
{
nonNegativeIntegerArgument(initialPopulationSize)
nonNegativeIntegerArgument(selfingGenerations)
positiveIntegerArgument(nSeeds)
nonNegativeIntegerArgument(intercrossingGenerations)
if(initialPopulationSize <= 2 && intercrossingGenerations > 0)
{
stop("Random mating is impossible with only two lines per generation")
#....and more importantly it means that the sample command below gets screwed up, because we're calling sample(x) where length(x) == 1, which samples from 1:x
}
return(.Call("fourParentPedigreeSingleFunnel", as.integer(initialPopulationSize), as.integer(selfingGenerations), as.integer(nSeeds), as.integer(intercrossingGenerations), PACKAGE="mpMap2"))
}
fourParentPedigreeSingleFunnelPrototype <- function(initialPopulationSize, selfingGenerations, nSeeds = 1L, intercrossingGenerations)
{
nonNegativeIntegerArgument(initialPopulationSize)
nonNegativeIntegerArgument(selfingGenerations)
positiveIntegerArgument(nSeeds)
intercrossingGenerations <- as.integer(intercrossingGenerations)
initialPopulationSize <- as.integer(initialPopulationSize)
if(initialPopulationSize <= 2 && intercrossingGenerations > 0)
{
stop("Random mating is impossible with only two lines per generation")
#....and more importantly it means that the sample command below gets screwed up, because we're calling sample(x) where length(x) == 1, which samples from 1:x
}
#Four founders, + 6 pairs + intialPopulationSize funnels
entries <- 4L + 2L + initialPopulationSize + intercrossingGenerations*initialPopulationSize + nSeeds*selfingGenerations*initialPopulationSize
mother <- father <- rep(NA, entries)
observed <- rep(FALSE, entries)
lineNames <- paste0("L", 1:entries)
mother[1:4] <- father[1:4] <- 0L
#Crosses of the founders
mother[5:6] <- c(1L, 3L)
father[5:6] <- c(2L, 4L)
#line 5 = 1,2
#line 6 = 3,4
mother[6+1:initialPopulationSize] <- 5L
father[6+1:initialPopulationSize] <- 6L
currentIndex <- 7L
nextFree <- currentIndex + initialPopulationSize
if(intercrossingGenerations > 0)
{
for(i in 1:intercrossingGenerations)
{
for(lineCounter in nextFree:(nextFree+initialPopulationSize-1))
{
mother[lineCounter] <- lineCounter - initialPopulationSize
father[lineCounter] <- sample(setdiff((nextFree-initialPopulationSize):(nextFree-1), lineCounter - initialPopulationSize), 1)
}
currentIndex <- currentIndex + initialPopulationSize
nextFree <- nextFree + initialPopulationSize
}
}
#Now the selfing.
#First the case of one generation of selfing
if(selfingGenerations == 1)
{
#The line that we're going to self
for(lineCounter in currentIndex:(currentIndex+initialPopulationSize-1))
{
mother[nextFree:(nextFree+nSeeds-1)] <- father[nextFree:(nextFree+nSeeds-1)] <- lineCounter
observed[nextFree+nSeeds-1] <- TRUE
nextFree <- nextFree + nSeeds
}
}
else if(selfingGenerations > 1)
{
for(lineCounter in currentIndex:(currentIndex+initialPopulationSize-1))
{
#And the number of selfed lines coming off this one
for(seedCounter in 1:nSeeds)
{
father[nextFree:(nextFree+selfingGenerations-1)] <- mother[nextFree:(nextFree+selfingGenerations-1)] <- c(lineCounter, nextFree:(nextFree+selfingGenerations-2))
observed[nextFree+selfingGenerations-1] <- TRUE
nextFree <- nextFree + selfingGenerations
}
}
}
#No selfing
else
{
observed[(nextFree-initialPopulationSize):(nextFree-1)] <- TRUE
}
return(new("detailedPedigree", lineNames = lineNames, mother = mother, father = father, initial = 1L:4L, observed = observed, selfing = "infinite", warnImproperFunnels = TRUE))
}
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