data/example6.data.R

In sbihorel/scaRabee: Optimization Toolkit for Pharmacokinetic-Pharmacodynamic Models

example6.data <- data.frame(
OMIT = c(0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0),
ID = c(1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,2,2,2,2,2,2,2,2,
  2,2,2,2,2,2,2,2,2,2,2,2,2,2,2,2,2,2,2,2,3,3,3,3,3,3,3,3,3,3,3,3,3,3,3,3,3,3,3,
  3,3,3,3,3,3,3,3,3,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,5,5,
  5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,6,6,6,6,6,6,6,6,6,6,6,6,6,
  6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,
  7,7,7,7,8,8,8,8,8,8,8,8,8,8,8,8,8,8,8,8,8,8,8,8,8,8,8,8,8,8,8,8,9,9,9,9,9,9,9,
  9,9,9,9,9,9,9,9,9,9,9,9,9,9,9,9,9,9,9,9,9,10,10,10,10,10,10,10,10,10,10,10,10,
  10,10,10,10,10,10,10,10,10,10,10,10,10,10,10,10,11,11,11,11,11,11,11,11,11,11,
  11,11,11,11,11,11,11,11,11,11,11,11,11,11,11,11,11,11,12,12,12,12,12,12,12,12,
  12,12,12,12,12,12,12,12,12,12,12,12,12,12,12,12,12,12,12,12),
TRT = c(1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,
  1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,
  1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,
  1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,
  1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,
  1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,
  1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,
  1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,
  1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1),
TIME = c(0,0,0.25,0.25,0.5,0.5,1,1,1.5,1.5,2,2,3,3,4,4,6,6,8,8,12,12,16,16,20,
  20,24,24,0,0,0.25,0.25,0.5,0.5,1,1,1.5,1.5,2,2,3,3,4,4,6,6,8,8,12,12,16,16,20,
  20,24,24,0,0,0.25,0.25,0.5,0.5,1,1,1.5,1.5,2,2,3,3,4,4,6,6,8,8,12,12,16,16,20,
  20,24,24,0,0,0.25,0.25,0.5,0.5,1,1,1.5,1.5,2,2,3,3,4,4,6,6,8,8,12,12,16,16,20,
  20,24,24,0,0,0.25,0.25,0.5,0.5,1,1,1.5,1.5,2,2,3,3,4,4,6,6,8,8,12,12,16,16,20,
  20,24,24,0,0,0.25,0.25,0.5,0.5,1,1,1.5,1.5,2,2,3,3,4,4,6,6,8,8,12,12,16,16,20,
  20,24,24,0,0,0.25,0.25,0.5,0.5,1,1,1.5,1.5,2,2,3,3,4,4,6,6,8,8,12,12,16,16,20,
  20,24,24,0,0,0.25,0.25,0.5,0.5,1,1,1.5,1.5,2,2,3,3,4,4,6,6,8,8,12,12,16,16,20,
  20,24,24,0,0,0.25,0.25,0.5,0.5,1,1,1.5,1.5,2,2,3,3,4,4,6,6,8,8,12,12,16,16,20,
  20,24,24,0,0,0.25,0.25,0.5,0.5,1,1,1.5,1.5,2,2,3,3,4,4,6,6,8,8,12,12,16,16,20,
  20,24,24,0,0,0.25,0.25,0.5,0.5,1,1,1.5,1.5,2,2,3,3,4,4,6,6,8,8,12,12,16,16,20,
  20,24,24,0,0,0.25,0.25,0.5,0.5,1,1,1.5,1.5,2,2,3,3,4,4,6,6,8,8,12,12,16,16,20,
  20,24,24),
AMT = c(1000,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1000,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1000,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,1000,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,1000,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1000,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1000,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1000,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,1000,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1000,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1000,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1000,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0),
RATE = c(0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0),
CMT = c(1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,
  1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,
  1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,
  1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,
  1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,
  1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,
  1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,
  1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,
  1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1),
EVID = c(1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0),
DV = c(0,19.8657,99.9026,19.6569,97.244,17.2831,90.2029,15.8753,84.4154,15.9127,
  88.5158,14.1692,94.0105,10.8268,97.4056,9.40104,106.65,5.4872,112.914,3.85299,
  112.869,1.64896,110.862,0.707614,107.149,0.245623,106.416,0.11818,0,23.8592,
  85.6319,22.3474,78.879,19.0392,73.8635,18.0378,71.3095,15.3421,74.8796,
  15.1884,78.5095,11.2476,83.468,7.59395,94.2613,4.91195,94.2046,2.93962,
  94.7192,1.02773,89.0201,0.368248,89.6813,0.124715,85.6834,0.0456037,0,49.5461,
  110.248,48.7914,97.1696,46.4278,88.2857,37.3594,83.9774,33.1475,83.4144,
  28.2471,88.4591,22.3036,97.0282,16.6417,118.909,10.0842,133.926,5.33753,
  130.561,1.75019,121.55,0.551798,114.967,0.197986,117.468,0.0544853,0,34.4526,
  117.154,33.2472,106.03,30.1716,98.9318,26.4849,97.7173,21.9957,92.5396,
  19.1294,97.9732,13.4081,112.548,11.094,127.597,5.65481,134.263,2.99188,
  132.429,0.854194,124.029,0.239892,122.548,0.0689995,120.294,0.0195956,0,
  14.4954,91.6222,13.8169,84.7476,12.8147,82.7705,11.4995,78.9915,10.1621,
  81.7846,9.07089,89.3616,6.89213,88.7975,5.664,91.247,3.31404,95.333,2.06973,
  97.1632,0.769306,94.3457,0.307058,90.8385,0.120282,89.6403,0.0437878,0,
  34.5277,97.9031,31.754,89.6331,29.0383,82.6814,23.1647,75.487,22.2038,75.743,
  19.4092,84.2884,14.7542,90.3833,10.6868,108.214,6.67144,115.412,3.71005,
  113.222,1.35244,107.738,0.488253,106.634,0.162326,106.588,0.0539813,0,17.9503,
  112.059,16.8894,108.539,14.9212,101.992,14.5721,99.3583,12.3846,104.432,
  10.1263,104.151,7.94702,114.195,6.48571,122.909,3.77519,121.591,2.68551,
  121.589,1.17719,119.826,0.433197,118.146,0.162557,115.388,0.0623984,0,33.0174,
  114.743,32.9508,109.724,32.2249,99.5714,29.1032,93.9831,24.6738,96.8207,
  21.6967,98.655,17.3081,108.795,12.5376,123.027,8.56972,135.04,5.85754,136.524,
  2.36279,130.794,0.868009,126.764,0.368901,125.484,0.138854,0,18.6101,95.4547,
  17.2039,89.8894,17.1992,81.116,15.9002,84.8771,13.3332,84.6486,13.0094,
  87.6871,10.405,91.6875,7.90942,98.6514,5.77959,102.192,3.47671,101.49,1.68077,
  98.5969,0.794707,98.6242,0.319941,98.2974,0.152325,0,17.8566,105.776,16.0233,
  102.054,14.6838,97.6793,12.3728,98.6852,11.7892,95.0458,10.227,99.3405,
  7.52072,105.953,5.83135,111.932,3.68861,113.174,2.24186,112.599,0.836529,
  108.597,0.292715,109.44,0.111652,106.071,0.0401179,0,43.2326,81.9264,45.1451,
  79.1259,40.7317,69.0494,35.5903,69.1003,32.7768,65.5234,26.3118,71.7498,
  20.8959,79.7877,17.0406,90.3088,10.206,98.9043,7.10688,101.215,2.28209,
  95.9049,0.992102,93.1154,0.341086,90.526,0.140211,0,30.6723,82.1612,30.941,
  78.9632,25.3384,72.6674,23.9895,69.1737,19.7108,70.6498,18.4622,72.707,
  15.0601,77.9042,11.2593,89.6611,6.82318,95.4546,4.25245,95.1663,1.51197,
  87.5095,0.503576,87.5551,0.189608,88.363,0.0633599),
DVID = c(0,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,0,1,3,1,3,1,3,
  1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,0,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,
  3,1,3,1,3,1,3,1,3,1,0,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,0,
  1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,0,1,3,1,3,1,3,1,3,1,3,1,
  3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,0,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,
  1,3,1,3,1,0,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,0,1,3,1,3,1,
  3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,0,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,
  1,3,1,3,1,3,1,3,1,3,1,0,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,
  0,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1,3,1),
MDV = c(1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,
  0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,
  0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0)
)