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## function to calculate fisher sum
## p: vector of p-values
fisher.sum <- function(p, zero.sub=0.00001, na.rm=FALSE){
if(any(p>1, na.rm=TRUE)||any(p<0, na.rm=TRUE))
stop("You provided bad p-values")
stopifnot(zero.sub>=0 & zero.sub<=1 || length(zero.sub)!=1)
p[p==0] <- zero.sub
if(na.rm)
p<- p[!is.na(p)]
S= -2*sum(log(p))
res <- data.frame(S=S, num.p=length(p))
return(res)
}
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