ApplyPolygenicScore: Utilities for the Application of a Polygenic Score to a VCF

Simple and transparent parsing of genotype/dosage data from an input Variant Call Format (VCF) file, matching of genotype coordinates to the component Single Nucleotide Polymorphisms (SNPs) of an existing polygenic score (PGS), and application of SNP weights to dosages for the calculation of a polygenic score for each individual in accordance with the additive weighted sum of dosages model. Methods are designed in reference to best practices described by Collister, Liu, and Clifton (2022) <doi:10.3389/fgene.2022.818574>.

Package details

AuthorPaul Boutros [cre], Nicole Zeltser [aut] (<https://orcid.org/0000-0001-7246-2771>), Rachel Dang [ctb]
MaintainerPaul Boutros <PBoutros@mednet.ucla.edu>
LicenseGPL-2
Version3.0.1
Package repositoryView on CRAN
Installation Install the latest version of this package by entering the following in R:
install.packages("ApplyPolygenicScore")

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ApplyPolygenicScore documentation built on April 4, 2025, 12:18 a.m.