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BElikelihood: Likelihood Method for Evaluating Bioequivalence
A likelihood method is implemented to present evidence for evaluating bioequivalence (BE). The functions use bioequivalence data [area under the blood concentration-time curve (AUC) and peak concentration (Cmax)] from various crossover designs commonly used in BE studies including a fully replicated, a partially replicated design, and a conventional 2x2 crossover design. They will calculate the profile likelihoods for the mean difference, total standard deviation ratio, and within subject standard deviation ratio for a test and a reference drug. A plot of a standardized profile likelihood can be generated along with the maximum likelihood estimate and likelihood intervals, which present evidence for bioequivalence. See Liping Du and Leena Choi (2015) <doi:10.1002/pst.1661>.
Getting started
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Package details |
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| Author | Liping Du [aut, cre] (<https://orcid.org/0000-0003-4926-2135>), Leena Choi [aut] (<https://orcid.org/0000-0002-2544-7090>), Cole Beck [aut] (<https://orcid.org/0000-0002-6849-6255>) |
| Maintainer | Liping Du <liping.du@vumc.org> |
| License | GPL (>= 3) |
| Version | 1.1 |
| Package repository | View on CRAN |
| Installation |
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