The workflow is a versatile R package designed for comprehensive feature selection in bulk RNAseq datasets. Its key innovation lies in the seamless integration of the 'Python' 'scikit-learn' (<https://scikit-learn.org/stable/index.html>) machine learning framework with R-based bioinformatics tools. 'GeneSelectR' performs robust Machine Learning-driven (ML) feature selection while leveraging 'Gene Ontology' (GO) enrichment analysis as described by Thomas PD et al. (2022) <doi:10.1002/pro.4218>, using 'clusterProfiler' (Wu et al., 2021) <doi:10.1016/j.xinn.2021.100141> and semantic similarity analysis powered by 'simplifyEnrichment' (Gu, Huebschmann, 2021) <doi:10.1016/j.gpb.2022.04.008>. This combination of methodologies optimizes computational and biological insights for analyzing complex RNAseq datasets.
Package details |
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Author | Damir Zhakparov [aut, cre] (<https://orcid.org/0000-0001-7175-0843>) |
Maintainer | Damir Zhakparov <dzhakparov@gmail.com> |
License | MIT + file LICENSE |
Version | 1.0.1 |
URL | https://github.com/dzhakparov/GeneSelectR |
Package repository | View on CRAN |
Installation |
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