OmicsQC: Nominating Quality Control Outliers in Genomic Profiling Studies

A method that analyzes quality control metrics from multi-sample genomic sequencing studies and nominates poor quality samples for exclusion. Per sample quality control data are transformed into z-scores and aggregated. The distribution of aggregated z-scores are modelled using parametric distributions. The parameters of the optimal model, selected either by goodness-of-fit statistics or user-designation, are used for outlier nomination. Two implementations of the Cosine Similarity Outlier Detection algorithm are provided with flexible parameters for dataset customization.

Package details

AuthorAnders Hugo Frelin [aut], Helen Zhu [aut], Paul C. Boutros [aut, cre] (<https://orcid.org/0000-0003-0553-7520>)
MaintainerPaul C. Boutros <PBoutros@mednet.ucla.edu>
LicenseGPL-2
Version1.1.0
Package repositoryView on CRAN
Installation Install the latest version of this package by entering the following in R:
install.packages("OmicsQC")

Try the OmicsQC package in your browser

Any scripts or data that you put into this service are public.

OmicsQC documentation built on May 29, 2024, 11:14 a.m.