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dotgen: Gene-Set Analysis via Decorrelation by Orthogonal Transformation
Decorrelates a set of summary statistics (i.e., Z-scores or P-values per SNP) via Decorrelation by Orthogonal Transformation (DOT) approach and performs gene-set analyses by combining transformed statistic values; operations are performed with algorithms that rely only on the association summary results and the linkage disequilibrium (LD). For more details on DOT and its power, see Olga (2020) <doi:10.1371/journal.pcbi.1007819>.
Getting started
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Package details |
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| Author | Olga Vsevolozhskaya [aut] (<https://orcid.org/0000-0001-9376-3645>), Dmitri Zaykin [aut] (<https://orcid.org/0000-0002-9444-2859>), Xiaoran Tong [aut, cre] (<https://orcid.org/0000-0002-4648-3330>) |
| Maintainer | Xiaoran Tong <xt@uky.edu> |
| License | GPL (>= 2) |
| Version | 0.1.1 |
| URL | https://github.com/xiaoran831213/dotgen |
| Package repository | View on CRAN |
| Installation |
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