JunLiuLab/SIMPLEs: SIMPLEs: single-cell RNA sequencing imputation and cell clustering methods by modeling gene module variation

SIMPLE is a R package that imputes "dropout" values (i.e. zero or small entries) in the single cell RNASeq data based on cell similarities and gene correlations. The imputed matrix can be used for dimension reduction and visualization of the cell spectrum, to identify markers between different samples and construct gene co-expression network.

install.packages("remotes")
remotes::install_github("JunLiuLab/SIMPLEs")