Implementation of an iterative Lloyds type algorithm to separate multiple haplotypes from allele frequency data. The number of haplotypes is estimated via singular value thresholding. Then, the haplotype frequency matrix is initialized via a pre-clustering of the allele frequencies and an absolute value ordering of the centers. Haplotype structure and frequency matrix are updated iteratively until convergence.
Package details |
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Author | Merle Behr, Housen Li and Marta Pelizzola |
Maintainer | Merle Behr <behr@berkeley.edu>, Housen Li <housen.li@mathematik.uni-goettingen.de>, Marta Pelizzola <marta.pelizzola@vetmeduni.ac.at> |
License | GPL-2 |
Version | 0.1.0 |
Package repository | View on GitHub |
Installation |
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