YangLabHKUST/MR-APSS: The MRAPSS package implement the MR-APPSS approach to test for the causal effect of an exposure on a outcome disease.

The MRAPSS package implement the MR-APPSS approach to test for the causal effects between an exposure and a outcome disease. The MR-APPSS is a unified approach to Mendelian Randomization accounting for polygenicity, pleiotropy and sample structure using genome-wide summary statistics. Specifically, MR-APPSS uses a background-foreground model to characterize both SNP-exposure effects and SNP-outcome effects estimates, where the background model accounts for confounding from genetic correlation and sample structure and the foreground model captures the valid signal for causal inference.

install.packages("remotes")
remotes::install_github("YangLabHKUST/MR-APSS")