This package serves as an analytical pipeline for determining allele-specific translation. It first identifies genetic variants that are candidates for allele-specific translation (i.e. may lead to differential translation) by using RNA-Seq and Ribosome profiling data from all heterozygous SNPs in the transcriptome of a given individual. For each candidate SNP, a separate function determines whether the SNP does have allele-specific translation, using data from an experimental assay that combines polysome profiling and digital droplet PCR (ddPCR), which gives the distribution of number of ribosomes bound to the two alleles.
Package details |
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Maintainer | Angela Li <asli@stanford.edu> |
License | CC0 |
Version | 1.0.0 |
Package repository | View on GitHub |
Installation |
Install the latest version of this package by entering the following in R:
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