kdzimm/hierarchicell: Simulating Cell-Type Specific and Hierarchical Single-Cell RNA-Seq Data

A simulation engine that estimates important parameters from single-cell RNA-seq expression counts to simulate expression data that are cell-type specific and hierarchical in nature. The simulated data can then be used to compute power and type 1 error calculations under a variety of conditions. The package consists of four important categories of functions: data loading and cleaning, empirical estimation of distributions, simulating expression data, and computing power or type 1 error. KD Zimmerman, MA Espeland, CD Langefeld (2020) <doi:10.1101/2020.01.15.906248>.

install.packages("remotes")
remotes::install_github("kdzimm/hierarchicell")