A minimal set of routines to calculate the 'Grantham' distance <doi:10.1126/science.185.4154.862>. The 'Grantham' distance attempts to provide a proxy for the evolutionary distance between two amino acids based on three key chemical properties: composition, polarity and molecular volume. In turn, evolutionary distance is used as a proxy for the impact of missense mutations. The higher the distance, the more deleterious the substitution is expected to be.
Package details |
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Maintainer | |
License | MIT + file LICENSE |
Version | 0.1.1 |
URL | https://maialab.org/grantham/ https://github.com/maialab/grantham |
Package repository | View on GitHub |
Installation |
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