qiuanzhu/remss: Refining Evaluation Methodology on Stage System

TNM stage is important in treatment decision-making and outcome predicting. The existing oropharyngeal Cancer (OPC) TNM stages have not made distinction of the two sub sites of HPV+ and HPV- diseases.We developed novel criteria to assess performance of the TNM stage grouping schemes based on parametric modeling adjusting on important clinical factors. These criteria evaluate the TNM stage grouping scheme in five different measures: hazard consistency, hazard discrimination, explained variation, likelihood difference, and balance. The methods are described in Xu, W., et al. "Refining evaluation methodology on TNM stage system: assessment on HPV-related oropharyngeal cancer." Austin Biom Biostat 2 (2015): 1014.

install.packages("remotes")
remotes::install_github("qiuanzhu/remss")