zcslab/CSMR: A novel supervised clustering algorithm using penalized mixture regression model

Identifying relationships between molecular variations and their clinical presentations has been challenged by the heterogeneous causes of a disease. It is imperative to unveil the relationship between the high dimensional molecular manifestations and the clinical presentations, while taking into account the possible heterogeneity of the study subjects.We proposed a novel supervised clustering algorithm using penalized mixture regression model, called CSMR, to deal with the challenges in studying the heterogeneous relationships between high dimensional molecular features to a phenotype. The algorithm was adapted from the classification expectation maximization algorithm, which offers a novel supervised solution to the clustering problem, with substantial improvement on both the computational efficiency and biological interpretability.

install.packages("remotes")
remotes::install_github("zcslab/CSMR")