Strand-specific digital genomic footprinting in DNase-seq data. The cumulative Skellam distribution function (package 'skellam') is used to detect significant normalized count differences of opposed sign at each DNA strand. This is done in order to determine the protein-binding footprint flanks. Preprocessing of the mapped reads is recommended before running DNaseR (e.g., quality checking and removal of sequence-specific bias).
|Author||Pedro Madrigal <[email protected]>|
|Maintainer||Pedro Madrigal <[email protected]>|
|License||GPL-2 + file LICENSE|
|Package repository||View on Bioconductor|
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