This package provides functionality for kinase-subtrate prediction, and integration with phosphopeptide fold change and signficance to assess the local connectivity (swing) of kinase-substrate networks. The final output of KinSwingR is a score that is normalised and weighted for prediction of kinase activity.
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Builds PWMs for kinases from a table of kinases and known substrate sequences.
Score kinase PWMs matches against a set of peptide seqeuences.
Integrates kinase PWMs matches against peptide seqeuences and directionality as well as significance of peptides for prediction of kinase activity.
Function for extracting peptides from multimapped data
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