plotTopWeights: Plot top weights

In MOFA: Multi-Omics Factor Analysis (MOFA)

Description

Plot top weights for a given latent factor in a given view.

Usage

plotTopWeights(object, view, factor, nfeatures = 10, abs = TRUE,
  scale = TRUE, sign = "both")

Arguments

object	a trained MOFAmodel object.
view	character vector with the view name, or numeric vector with the index of the view to use.
factor	character vector with the factor name, or numeric vector with the index of the factor to use.
nfeatures	number of top features to display. Default is 10.
abs	logical indicating whether to use the absolute value of the weights. Default is TRUE.
scale	logical indicating whether to scale all loadings from 0 to 1. Default is TRUE.
sign	can be 'positive', 'negative' or 'both' to show only positive, negative or all weigths, respectively. Default is 'both'.

Details

The weights, or the loadings, provide the mapping between the high-dimensional space (the genes) and the low-dimensional space (the factors).
They define a score for each gene on each factor, such that genes with no association with the factor are expected to have values close to zero, whereas genes with strong association with the factor are expected to have large absolute values.
The sign of the loading indicates the direction of the effect: A positive loading indicates that the feature is more active in the cells with positive factor values, while a negative loading indicates that the feature is more active in the cells with negative factor values.

Value

Returns a ggplot2 object

Examples

# Example on the CLL data
filepath <- system.file("extdata", "CLL_model.hdf5", package = "MOFAdata")
MOFA_CLL <- loadModel(filepath)
plotTopWeights(MOFA_CLL, view="Mutations", factor=1, nfeatures=3)
plotTopWeights(MOFA_CLL, view="Mutations", factor=1, nfeatures=3, sign = "positive")
plotTopWeights(MOFA_CLL, view="Mutations", factor=1, nfeatures=3, sign = "negative")

# Example on the scMT data
filepath <- system.file("extdata", "scMT_model.hdf5", package = "MOFAdata")
MOFA_scMT <- loadModel(filepath)
plotTopWeights(MOFA_scMT, view="RNA expression", factor=1)

MOFA documentation built on Feb. 11, 2021, 2:01 a.m.