Data from the Sinha et al. 1999 and Boca et al. 2014 studies concerning the Navy Colorectal Adenoma case-control study.
The data consists of a dietary exposures of interest (daily intake of fish in grams/day), the outcome of interest (colorectal adenoma status), and 149 serum metabolites which are possible mediators between either of the exposures and the outcome. Four other additional covariates of interest are included (body mass index, gender, age, current smoking status.)
Data frame with 258 rows, representing 129 cases and 129 controls in the Navy Colorectal Adenoma study. There are 155 columns, ordered as follows: fish intake (Fish), body mass index (BMI), gender (Female - coded as 0 for male, 1 for female), age in years (Age), current smoking status (Smoking - coded as 0 for non-smoker, 1 for current smoker), 149 serum metabolites (values were previously batch normalized and log transformed), and case-control status for adenoma (Adenoma - coded as 0 for control, 1 for case.)
Sinha, R, Chow WH, Kulldorff M, Denobile J, Butler J, Garcia-Closas M, Weil R, Hoover RN, Rothman N. (1999) Well-done, grilled red meat increases the risk of colorectal adenomas. Cancer Res., 59(17), 4320-4324.
Boca SM, Sinha R, Cross AJ, Moore SC, Sampson JN. (2014) Testing multiple biological mediators simultaneously. Bioinformatics, 30(2), 214-220.