PAIRADISE: PAIRADISE Detecting allele-specific alternative splicing from...
In PAIRADISE: PAIRADISE: Paired analysis of differential isoform expression

We introduce PAIRADISE (PAIred Replicate analysis of Allelic DIfferential Splicing Events), a method for detecting allele-specific alternative splicing (ASAS) from RNA-seq data. PAIRADISE uses a statistical model that aggregates ASAS signals across multiple individuals in a population. It formulates ASAS detection as a statistical problem for identifying differential alternative splicing from RNA-seq data with paired replicates. The PAIRADISE statistical model is applicable to many forms of allele-specific isoform variation (e.g. RNA editing), and can be used as a generic statistical model for RNA-seq studies involving paired replicates.

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PAIRADISE documentation built on Nov. 8, 2020, 8:22 p.m.