Roleswitch: Infer miRNA-mRNA interactions using paired expression data from a single sample

Infer Probabilities of MiRNA-mRNA Interaction Signature (ProMISe) using paired expression data from a single sample. Roleswitch operates in two phases by inferring the probability of mRNA (miRNA) being the targets ("targets") of miRNA (mRNA), taking into account the expression of all of the mRNAs (miRNAs) due to their potential competition for the same miRNA (mRNA). Due to dynamic miRNA repression in the cell, Roleswitch assumes that the total transcribed mRNA levels are higher than the observed (equilibrium) mRNA levels and iteratively updates the total transcription of each mRNA targets based on the above inference. NB: in the paper, we used ProMISe as both the model name and inferred score name.

AuthorYue Li
Date of publicationNone
MaintainerYue Li <yueli@cs.toronto.edu>
LicenseGPL-2
Version1.12.0
http://www.cs.utoronto.ca/~yueli/roleswitch.html

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Files

Roleswitch/DESCRIPTION
Roleswitch/NAMESPACE
Roleswitch/R
Roleswitch/R/diagnosticPlot.R Roleswitch/R/getSeedMatrix.R Roleswitch/R/roleswitch.R
Roleswitch/build
Roleswitch/build/vignette.rds
Roleswitch/data
Roleswitch/data/datalist
Roleswitch/data/tcga_gbm_testdata.RData
Roleswitch/inst
Roleswitch/inst/CITATION
Roleswitch/inst/NEWS
Roleswitch/inst/doc
Roleswitch/inst/doc/Roleswitch.R
Roleswitch/inst/doc/Roleswitch.Rnw
Roleswitch/inst/doc/Roleswitch.pdf
Roleswitch/man
Roleswitch/man/Roleswitch-package.Rd Roleswitch/man/diagnosticPlot.Rd Roleswitch/man/getSeedMatrix.Rd Roleswitch/man/roleswitch.Rd Roleswitch/man/tcga_gbm_testdata.Rd
Roleswitch/vignettes
Roleswitch/vignettes/Roleswitch.Rnw
Roleswitch/vignettes/Roleswitch.bib

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