Metabolic response to starvation was studied in two microbes, Escherichia coli and Saccharomyces cerevisae, to determine whether metabolome response to nutrient deprivation is similar across both organisms. Sixty-eight cellular metabolites were analyzed by LC-MS/MS in both bacteria and yeast, after nutrient starvation with carbon and nitrogen. Cells were sampled for 8 hours.
An ExpressionSet with metabolite x sample intensity data and sample information. Intensity data comprise the logtransformed relative metabolite concentration changes with respect to experiment initiation at time point 0 hrs. For the samples, information is provided on species (Bacteria vs Yeast), starvation (Carbon vs Nitrogen) and time point in hrs.
Anneleen Daemen, Matthew Brauer
Brauer MJ, Yuan J, Bennett BD, et al. Conservation of the metabolomic response to starvation across two divergent microbes. Proc Nat Acad Sci U.S.A. 103(51), 19302-19307 (2006).