This dataset represents chromosome 21 from the IMR90 and H1 cell lines sequenced in Lister et al. Only CpG methylation are included. The two samples from each cell line are two different extractions (ie. technical replicates), and are pooled in the analysis in the original paper.
An object of class
All coordinates are in hg18.
the files mc_h1_r1.tar.gz, mc_h1_r2.tar.gz,
A script which downloads these files and constructs the
object may be found in ‘inst/scripts/get_BS.chr21.R’ - this was
based off of and modified from the get_BS.chr22.R script in the
bsseq package. The object constructed here contains a
different chromosome (22 instead of 21), and two additional samples
(h1 and imr90 instead of just imr90) to enable identification of
cell type-DMRs for examples.
R Lister et al. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 462, 315-322.
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