AbSim: Time Resolved Simulations of Antibody Repertoires

Simulation methods for the evolution of antibody repertoires. The heavy chain variable region of both human and C57BL/6 mice can be simulated in a time-dependent fashion. Both single lineages using one set of V-, D-, and J-genes or full repertoires can be simulated. The algorithm begins with an initial VDJ recombination event, starting the first phylogenetic tree. Upon completion, the main loop of the algorithm begins, with each iteration representing one simulated time step. Various mutation events are possible at each time step, contributing to a diverse final repertoire.

AuthorAlexander Yermanos
Date of publication2016-12-15 00:04:12
MaintainerAlexander Yermanos <ayermano@ethz.ch>
LicenseGPL-2
Version0.1

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Files in this package

AbSim
AbSim/inst
AbSim/inst/doc
AbSim/inst/doc/vignette.Rmd
AbSim/inst/doc/vignette.R
AbSim/inst/doc/vignette.html
AbSim/NAMESPACE
AbSim/R
AbSim/R/sysdata.rda
AbSim/R/clonalExpansion.R AbSim/R/data.R AbSim/R/singleLineage.R AbSim/R/internal.R AbSim/R/fullRepertoire.R
AbSim/vignettes
AbSim/vignettes/vignette.Rmd
AbSim/MD5
AbSim/build
AbSim/build/vignette.rds
AbSim/DESCRIPTION
AbSim/man
AbSim/man/hum_v_df.Rd AbSim/man/one_spot_df.Rd AbSim/man/singleLineage.Rd AbSim/man/blc6_j_df.Rd AbSim/man/blc6_v_df.Rd AbSim/man/hum_j_df.Rd AbSim/man/blc6_d_df.Rd AbSim/man/clonalExpansion.Rd AbSim/man/hum_d_df.Rd AbSim/man/hotspot_df.Rd AbSim/man/fullRepertoire.Rd

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